Anti-government protesters in Egypt have stormed the national headquarters of President Mohammed Morsi's Muslim Brotherhood in the capital, Cairo.
People ransacked the building in the Moqattam area and set parts on fire.
Officials say eight people have been killed in clashes outside since Sunday, while eight others have died elsewhere.
Earlier, the opposition movement behind the protests that saw millions take to the streets across Egypt on Sunday gave Mr Morsi until Tuesday to resign.
Tamarod (Rebel) said Mr Morsi would face a campaign of civil disobedience if he did not leave power and allow elections to be held.
Analysis
All sides in Egypt were surprised by the huge scale of the demonstrations against the president.
The opposition is a broad and informal coalition, which ranges from supporters of the old Mubarak regime to people who risked their lives to topple it. Their challenge is to find a way to sustain the momentum of Sunday's protests.
President Morsi's spokesman has called for dialogue. For that to work, the president would have to offer major concessions, perhaps on a rewritten constitution. He showed no signs of conciliation during a major political speech last week, instead appealing to his Muslim Brotherhood base.
As for the demonstrators, they have called for his resignation and early elections. Political chaos looks likely to continue.
Meanwhile, four government ministers were reported to have resigned. The al-Watan website said they had done so "in solidarity with the people's demand to overthrow the regime".
Protesters across Egypt accuse the president of failing to tackle economic and security problems since being elected a year ago. His supporters insist he needs more time.
'Thugs'Millions of people attended demonstrations across the country on Sunday to demand Mr Morsi step down.
The crowds seen in Cairo's Tahrir Square were the biggest since the 2011 revolution that toppled Hosni Mubarak.
Sporadic outbreaks of violence were reported nationwide.
The health ministry said at least 16 people had been killed and 781 injured across the country since Sunday. Three people died in the central province of Assiut, and another four in Alexandria, Fayoum, Beni Suef and Kafr al-Sheikh.
Another protester suffocated to death at a protest outside the Ittihadiya presidential palace in Cairo, while eight were killed in clashes around the Muslim Brotherhood's headquarters in Moqattam, the ministry added.
Overnight, protesters threw petrol bombs and rocks at armed guards inside the six-storey building, who retaliated by firing at them.
On Monday morning, the protesters stormed the headquarters and began throwing objects of broken windows. One protester was seen removing parts of the signage, while another waved an Egyptian flag from a window.
Some people took away office equipment, as well as furniture, rugs and air conditioning units.
Continue reading the main story"This is a historic moment. The Brotherhood ruined the country, so stealing from them is justified," one man, named Mohammed, told the AFP news agency.
Many protesters accuse the president of putting the Brotherhood's interests ahead of the country's as a whole.
A Brotherhood spokesman blamed the violence on "thugs" and said it would be demanding the police explain why officers had failed to protect the group's headquarters.
Two people inside had been injured by fires before a Brotherhood security detail could evacuate them on Monday morning, he told the Reuters news agency.
'Constitutional legitimacy'Meanwhile, some protesters spent the night camped out in Tahrir Square and also in front of the Ittihadiya presidential palace to the north-east. They vowed to stay there until the president stepped down.
One man heading to the palace was confident it would not take long.
Tamarod (Rebel)
The Tamarod movement says more than 22 million people have signed a petition complaining that:
- Security has not been restored since the 2011 revolution that toppled Hosni Mubarak
- The poor "have no place" in society
- The government has had to "beg" the International Monetary Fund (IMF) for a $4.8bn loan to help shore up the public finances
- There has been "no justice" for people killed by security forces during the uprising and at anti-government protests since then
- "No dignity is left" for Egyptians or their country
- The economy has "collapsed", with growth poor and inflation high
- Egypt is "following in the footsteps" of the US
"Mubarak took only 18 days although he had behind him the security, intelligence and a large sector of Egyptians," Amr Tawfeeq told the Associated Press.
Earlier, Tamarod issued a statement saying the protesters would give Mr Morsi until 17:00 (15:00 GMT) on Tuesday to leave power and allow state institutions to prepare for early presidential elections.
Otherwise, people would begin a campaign of "complete civil disobedience", the group warned.
It urged "state institutions including the army, the police and the judiciary, to clearly side with the popular will as represented by the crowds".
The group also rejected offers of dialogue from the president.
"There is no way to accept any half measures," it said. "There is no alternative other than the peaceful end of power of the Muslim Brotherhood and its representative, Mohammed Morsi."
On Saturday, Tamarod said it had collected more than 22 million signatures - more than a quarter of Egypt's population - in support.
But Mr Morsi was defiant in an interview published on Sunday, rejecting the opposition calls for early presidential elections.
"If we changed someone in office who [was elected] according to constitutional legitimacy - well, there will be people opposing the new president too, and a week or a month later they will ask him to step down," he told the Guardian newspaper.
He said he would not tolerate any deviation from constitutional order.
"There is no room for any talk against this constitutional legitimacy. There can be demonstrations and people expressing their opinions," he added. "But what's critical in all this is the adoption and application of the constitution. This is the critical point."
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