A large bomb has gone off in the west of the Afghan capital, Kabul, near the compound where a security pact with the US is to be debated, police say.
At least one person has died in the blast, thought to have been caused by a suicide car bomber.
The security pact governs the status of the 10,000 US military personnel staying in Afghanistan beyond 2014.
It is being discussed next week by Afghanistan's Loya Jirga, the traditional council of elders.
A police chief, quoted by the AFP news agency, spoke of an explosives-laden car and one witness described seeing a white vehicle in the area before the blast.
The explosion occurred less than 100 metres from a large tent where more than 2,000 prominent Afghans will gather on Thursday to debate the pact.
A defence ministry official was quoted as saying the attacked targeted an armoured car providing security for the Loya Jirga.
One report suggested 10 people may have been killed, but officials are making clear that the death toll is not yet clear.
The security agreement must be approved by the Loya Jirga and parliament before it can come into force.
Among other issues, the pact covers the key issue of whether US troops can be prosecuted in Afghanistan.
Hours before the blast, Mr Karzai said negotiators had completed a draft of the accord, AP reports.
But he added that there were "still some differences".
The US contingent remaining beyond the end of 2014, when most international forces are due to have left Afghanistan, is expected to focus on training and mentoring Afghan security forces.
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