Teenage cancer fundraiser Stephen Sutton has died peacefully in his sleep, his mother said on his Facebook page.
The 19-year-old, from Burntwood in Staffordshire, raised more than £3.2m for the Teenage Cancer Trust after news of his plight spread on social media.
In a post announcing Stephen's death, Jane Sutton said he was a "courageous, selfless, inspirational son".
Stephen was diagnosed with terminal cancer aged 15.
'True hero'Ms Sutton added: "The ongoing support and outpouring of love for Stephen will help greatly at this difficult time, in the same way as it helped Stephen throughout his journey."
Stephen was readmitted to hospital on Sunday after developing breathing difficulties caused by the re-growth of tumours.
He had initially set out to raise just £10,000 for charity, but his fundraising campaign attracted huge attention last month after he posted a 'final' selfie online.
A number of celebrities and public figures paid tribute to Stephen after news of his death emerged.
Prime Minister David Cameron tweeted: "I'm deeply saddened to hear that Stephen Sutton has died. His spirit, bravery and fundraising for cancer research were all an inspiration."
Comedian Ricky Gervais tweeted: "RIP Stephen Sutton. A true hero & inspiration to us all."
TV presenter Clare Balding added : "Desperately sad to hear that Stephen Sutton has died. I feel privileged to have met him and heard him speak."
The Teenage Cancer Trust, to which Stephen made the largest ever single donation in its history, said: "We are humbled and hugely grateful for what Stephen achieved and continues to achieve for us."
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