Patient safety must be our priority, England's chief nursing officer has said, ahead of the first NHS strike over pay in more than 30 years.
Jane Cummings said "robust plans" were in place and urged patients to "bear with us".
She said staff were "professional" and would "think carefully" about action.
Nurses, midwives and ambulance staff are among those in England and Northern Ireland set to walk out from 07:00 until 11:00 BST.
The strike by six unions is mainly taking place in England, although members of the GMB union in Northern Ireland are involved.
Services could be disrupted although urgent and emergency care - including maternity - is not being targeted.
The strike is intended to disrupt more routine areas of care, which could result in patient transport services not running and antenatal and postnatal clinics being cancelled.
Ms Cummings appealed to staff taking part in the strike to think about their patients.
"They do the job which is hard, they work very hard and they put the safety of patients first," she told the BBC.
"So I would say to staff, I know that you're professional, I know that you will think very carefully about any action you take tomorrow. But our patient safety must be our priority and I know that's what staff will be thinking of."
The unions taking part have more than 400,000 members in the NHS in England out of 1.3 million staff.
However, not all of them will be involved because some will continue to provide what the unions have called "life and limb cover".
The walkout will be followed by four days of working-to-rule from Tuesday.
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