One person has died in a crash involving more than 40 vehicles on the M40 in Oxfordshire.
The motorway has been closed northbound between junction 9 at Bicester and junction 10 at Cherwell Valley services. The crash happened at about 07:45 GMT.
Thames Valley Police said one person died at the scene and another had sustained life-threatening injuries.
Six people have been seriously injured and up to 45 have minor injuries.
South Central Ambulance Service said it was foggy at the time of the "major collision".
Police said the road would be closed "for a number of hours" and have warned motorists to avoid the area because of "heavy traffic congestion".
The force said officers were working to relieve traffic stuck on the northbound carriageway.
A couple of southbound lanes are also shut along the same stretch.
On Twitter, Zara Smith, who was stuck at junction 9, said a number of lorries had jackknifed in "thick fog".
"Lots of people were walking around but the police are working hard to turn us round," she said.
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