A 59-year-old man from York has been arrested on suspicion of murdering missing chef Claudia Lawrence.
Miss Lawrence, who was 35 when she disappeared from her home in the city in 2009, has not been found, North Yorkshire Police said.
A force spokesman said forensic examinations were being conducted and were expected to continue for several days.
Police said a car was seized and further arrests could not be ruled out.
The force have not said where the new forensic examinations were taking place.
Miss Lawrence, who lived in Heworth, worked at the University of York and had been due to start a shift at 06:00 on 19 March but failed to turn up.
She was reported missing by her father, Peter, 67, the following day.
Extensive searches of the area were made but she was not found and police have since treated her disappearance as murder.
North Yorkshire Police launched a review of the case last year and have carried out new forensic work and searches of Miss Lawrence's home.
A fresh appeal for information was made on the fifth anniversary of her disappearance in March, which was broadcast on the BBC's Crimewatch programme.
Police revealed several new lines of inquiry generated by the review of the case and a fresh examination of her home.
Fingerprints had been uncovered using techniques not available in 2009, they said.
A DNA profile of a man was also found on a cigarette end discovered in Miss Lawrence's Vauxhall Corsa.
North Yorkshire Police said the Lawrence family had been informed of the arrest and were being offered support.
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